芦丁
槲皮素
肠道菌群
非酒精性脂肪肝
生物化学
生物
某种肠道细菌
化学
食品科学
脂肪肝
内科学
医学
抗氧化剂
疾病
作者
Zunji Shi,Ce Zhang,Hehua Lei,Chuan Chen,Zheng Cao,Yuanlin Song,Gui Chen,Fang Wu,Jian Zhou,Yu‐Jing Lu,Limin Zhang
标识
DOI:10.1021/acs.jafc.2c06212
摘要
The sugar moieties of natural flavonoids determine their absorption, bioavailability, and bioactivity in humans. To explore structure-dependent bioactivities of quercetin, isoquercetin, and rutin, which have the same basic skeleton linking different sugar moieties, we systemically investigated the ameliorative effects of dietary these flavonoids on high-fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) of mice. Our results revealed that isoquercetin exhibits the strongest capability in improving NAFLD phenotypes of mice, including body and liver weight gain, glucose intolerance, and systemic inflammation in comparison with quercetin and rutin. At the molecular level, dietary isoquercetin markedly ameliorated liver dysfunction and host metabolic disorders in mice with NAFLD. At the microbial level, the three flavonoids compounds, especially isoquercetin, can effectively regulate the gut microbiota composition, such as genera Akkermansia, Bifidobacterium, and Lactobacillus, which were significantly disrupted in NAFLD mice. These comparative findings offer new insights into the structure-dependent activities of natural flavonoids for NAFLD treatment.
科研通智能强力驱动
Strongly Powered by AbleSci AI