Testing a Dietary Intervention Called parts per thousand Pro-Heartt" to Reduce Adiposity and Enhance Cardiac Structure, Functional Status, Lipid Profiles, Glycemic Control, and Quality Of Life in Obese, Diabetic Patients with Advanced Heart Failure

CORE 5. MYOCARDIUM: FUNCTION AND FAILURE SESSION TITLE: HEART FAILURE WITH PRESERVED EJECTION FRACTION AND RELATED DISORDERS Abstract 18390: Testing a Dietary Intervention Called %oPro- Heart to Reduce Adiposity and Enhance Cardiac Structure, Functional Status, Lipid Profiles, Glycemic Control, and Quality Of Life in Obese, Diabetic Patients with Advanced Heart Failure Lorraine S Evangelista, Dawn Lombardo, Dan Cooper, Tamara Horwich and Gregg C Fonarow Publlshed: November 20, 2012 Article Info & Metrics eletters ,.. Jumpto Abstract BACKGROUND: To date, no known clinical trials have been done to test the effects of high protein (HP) diets in obese, diabetic patients with heart failure (HF). The goal of this four-year study is to explicate the role of HP diets in delaying the progression of disease in 90 patients with HF, New York Heart Association class II and Ill, body mass index (BMI) ~30 kglm 2 , and diabetes mellitus. We hypothesize that participants randomized to the HP diet compared to a standard protein (SP) diet will show greater reductions in adiposity (e.g. weight, waist circumference, percent body fat) and greater improvements in cardiac structure, functional status, lipid profiles, glycemic control, and quality of life following the 12-week intervention and that these changes will be maintained overtime. METHODS/DESIGN: Recruitment and enrollment in this prospective, two-group, randomized trial is on-going; participants are randomized to either a HP diet which consists of 30% protein (-110 g/day), 40% carbohydrates (CHO, -150 g/day) and 30% fat (-50 g/day) or standard protein (SP) diet which consists of 15% protein (-55 g/day), 55% CHO (-200 g/day) and 30% fat (-50 g/day). Participants will complete an intensive 12-week