Objective: To investigate the psychosocial risk factors of breast cancer.Methods: 31 diagnosed patients with breast cancer and matched 31 normal health women entering the study were requested to test the psychological rating scales(LES,SSRS,ENRICH,TCSQ).Results: The patients had experienced significantly more stressful life events,and had lower quality in marriage,and more often used negatively coping style than the controls(P0.05),during the last 5 years before diagnosis.The conditioned Logistic regressive analysis found that the important variables that had significant relationship with breast cancer were stressful life events,objective social support and negative coping style.Conclusion:Psychosocial stressful factors,such as stressful life events,lack of available psychosocial support,and negative coping styles are one of the important risk factors in the onset and progression of breast cancer in women.