Irritation study on the marine low temperature alkaline proteinase

To further study the irritation of marine low temperature alkaline proteinase and provide experimental data for its utilization. The safety of marine low temperature alkaline proteinase was evaluated by acute and chronic dermal irritation and acute eye irritation on rabbits. The results show that the skin experiment with marine low temperature alkaline proteinase (5‰,20%) dont cause swollen and redness of the skin. It has no irritation effect on the skin. The marine low temperature alkaline proteinase (40%) has middle irritation on the skin. Pathologic study shows that no chronic irritation effect of marine low temperature alkaline proteinase(5‰)on the skin has been found. The 1‰ solution for marine low temperature alkaline proteinase has no accute irritation effect on the eye.