An efficient synthesis of ferumoxytol induced by alternating-current magnetic field

Ferumoxytol (Feraheme™), as one kind of magnetic nanoparticles (MNPs), was approved for clinical application in USA and widely used as magnetic resonance imaging (MRI) agent in tumor and inflammation for preclinical diagnosis research. In this study, we explored a novel synthesis of ferumoxytol induced by alternating-current magnetic field (ACMF). As-prepared ferumoxytol was characterized by transmission electron microscopy (TEM), particle size analyzer, fourier transform infrared spectrometer (FT-IR), X-ray diffraction (XRD), vibrating sample magnetometer (VSM) and heating measurement in ACMF. Relative characterizations proved that as-synthesized ferumoxytol demonstrated better quality than Feraheme™ that was prepared by ordinary chemical co-precipitation on particle size distribution, crystallinity and magnetism. Above all, this ACMF induced synthesis may offer a better strategy for ferumoxytol preparation.