Affinity purification of pbmc Tlr-4 of Intestinal cancer patients

Toll-like receptors (TLRs) play a critical role in host defense from microbial infection. TLRs recognize conserved molecular structures produced by microorganisms and induce activation of innate and adaptive immune responses. The inflammatory responses induced by TLRs play an important role TLRs not only in host defense from infection, but also in tissue repair and regeneration. This latter function of TLRs can also contribute to tumorigenesis. Recent findings show that functional TLRs are expressed not only on immune cells but also on cancer cells. TLRs play an active role in carcinogenesis and tumor progression during chronic inflammation that involves the tumor microenvironment. Damage-associated molecular patterns (DAMPs) derived from injured normal epithelial cells and necrotic cancer cells appear to be present at significant levels in the tumor microenvironment, and their stimulation of specific TLRs can foster chronic inflammation. These TLRs those are expresses on tumor cells are related to interactions between cancer cells, immune cells, and DAMPs through TLR activation in the tumor microenvironment. This review discusses how the TLR is responsible for both providing immune response for various disease associated pathogens and how it involves in the carcinogenesis, cancer progression and metastasis