静息状态功能磁共振成像
扁桃形结构
迷走神经张力
背景(考古学)
海马结构
边缘系统
海马体
心理学
神经科学
发展心理学
混淆
医学
心率
听力学
自主神经系统
中枢神经系统
内科学
生物
古生物学
血压
作者
Stella Tsotsi,Anne Rifkin‐Graboi,Jessica L. Borelli,Yap Seng Chong,Victor Samuel Rajadurai,Chua Mei Chien,Birit F. P. Broekman,Michael J. Meaney,Anqi Qiu
标识
DOI:10.1016/j.jpsychires.2021.11.010
摘要
Parasympathetic nervous system (PNS) activity is important to physiological regulation. Limbic structures are important in determining what information the PNS receives, potentially influencing concurrent physiological responsivity and, ultimately, shaping PNS development. Yet, whether individual differences in these structures are linked to PNS activity in early childhood remains unclear. Here, in an exploratory capacity, we examined the association between neonatal limbic structures (i.e., the left and right amygdala and hippocampus) and preschoolers' resting-state respiratory sinus arrhythmia (RSA). RSA is a measure of heart-rate variability, a physiological marker that reflects fluctuation in the PNS and is often found predictive of emotion regulation and psychological wellbeing. Data were extracted from the "Growing Up in Singapore towards Healthy Outcomes" (GUSTO) cohort (n = 73, 39 girls). Neonatal limbic volume was collected within two weeks after birth while infants were asleep. Resting-state RSA was collected during a coloring session at 42 months of age. After controlling for potential confounders, a Bonferroni-corrected significant association between neonatal left hippocampal volume and resting-state RSA emerged wherein larger hippocampal volume was associated with higher resting-state RSA. No significant associations were present between resting-state RSA and right or left amygdala, or right hippocampal volume. These findings contribute to an increasing body of evidence aiming at enhancing our understanding of neurobiological underpinnings of parasympathetic activity and modulation. Results are also discussed with reference to ideas concerning biological sensitivity to context, as both left hippocampal volume and resting-state RSA were previously found to moderate associations between adversity and psychological function.
科研通智能强力驱动
Strongly Powered by AbleSci AI