富马酸二甲酯
电泳剂
激活剂(遗传学)
炎症
体外
化学
Jurkat细胞
消炎药
药理学
生物化学
立体化学
作者
Yong Zhang,Yujun Zhou,Jingshu Tang,Jiaqi Lan,Yuying Kang,Lei Wu,Ying Peng
标识
DOI:10.1080/10286020.2021.1949303
摘要
Dimethyl itaconate (DMI) is an analog of dimethyl fumarate (DMF), an approved NF-E2-related Factor 2 (Nrf2) activator for multiple sclerosis. This study evaluated the potential of DMI as an anti-inflammatory agent by comparing DMI with DMF in electrophilicity, Nrf2 activation, and anti-inflammation in vitro. The results showed that DMI was less electrophilic but better at inducing a durable activation of Nrf2 when compared with DMF. However, DMI demonstrated poor anti-inflammatory effects in Jurkat cells, bone marrow-derived dendritic cells, and RAW264.7 cells. Our study suggested that DMI was a potent electrophilic Nrf2 activator but was probably not a promising anti-inflammatory agent.
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