光热治疗
体内
免疫疗法
光动力疗法
免疫系统
癌症研究
免疫原性细胞死亡
菁
材料科学
生物物理学
癌症
化学
医学
免疫学
纳米技术
荧光
生物
内科学
有机化学
生物技术
物理
量子力学
作者
Shenglin Luo,Xi Luo,Xiaojia Wang,Lian Li,Huiguo Liu,Banghui Mo,Hongbo Gan,Wei Sun,Liting Wang,Houjie Liang,Songtao Yu
出处
期刊:Small
[Wiley]
日期:2022-06-02
卷期号:18 (27)
被引量:19
标识
DOI:10.1002/smll.202201298
摘要
Cancer immunotherapy has great potential in tumor eradication and metastasis suppression. However, systemic administration of immune adjuvants and inadequate specificity in cancer treatment, lead to restricted therapeutic benefits and potential immune-related side effects in clinical settings. In this report, the synthesis of various lengths of heptamethine cyanine small molecules to act as multifunctional photosensitizers (PS) for tumor-specific accumulation, near-infrared (NIR) fluorescent imaging, and photodynamic/photothermal/immunotherapy is optimized. In particular, it is demonstrated that C8, which contains eight carbons on two N-alkyl side chains, efficiently self-assembles with albumin to form nanosized dye-albumin complexes. This feature facilitates C8 in vivo self-assembly to remarkably improve its water-solubility, NIR fluorescent emission, long-term blood circulation, as well as tumor-specific accumulation. More importantly, C8 not only exhibits a superior phototherapeutic effect on primary tumors, but also elicits secretion of damage associated molecular patterns, cytokine secretion, dendritic cell maturation, and cytotoxic T lymphocytes activation, ultimately triggering a sufficient antitumor immune response to suppress growths of distant and metastatic tumors. Hence, this multifunctional small molecular PS is characterized with excellent tumor-preferential accumulation, imaging-guided laser irradiation, and phototherapy-induced in situ antitumor immune response, providing a prospective future of its use in tumor-targeting immunotherapy.
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