Visible‐Light‐Driven Conversion of Alcohols into Iodide Derivatives with Iodoform

Abstract A cost‐effective, straightforward, and environmentally benign alcohol iodination procedure with broad substrate scope is reported herein. In this reaction system, visible light and iodoform are employed as the energy source and iodination reagent, respectively. The reaction begins with the homolytic fission of the C–I bond in iodoform induced by visible‐light irradiation, producing active radicals. The following steps involve radical trapping by DMF (dimethylformamide), nucleophilic substitution, Vilsmeier‐type reagent formation, and the final iodination of the alcohol. The excellent performance of the model reaction in the flow photoreactor demonstrates the potential of this system for practical application.