姜黄素
TLR4型
肿瘤坏死因子α
细胞粘附分子
炎症
载脂蛋白E
化学
Toll样受体
受体
脂多糖
VCAM-1
基因剔除小鼠
药理学
内分泌学
免疫学
ICAM-1
医学
内科学
生物化学
先天免疫系统
疾病
作者
Shanshan Zhang,Jun Zou,Peiyang Li,Xizhong Zheng,Dan Feng
标识
DOI:10.1021/acs.jafc.7b04260
摘要
Toll-like receptor 4 (TLR4) has been reported to play a critical role in the pathogenesis of atherosclerosis, the current study aimed to investigate whether curcumin suppresses atherosclerosis development in ApoE-knockout (ApoE–/–) mice by inhibiting TLR4 expression. ApoE–/– mice were fed a high-fat diet supplemented with or without curcumin (0.1% w/w) for 16 weeks. Curcumin supplementation significantly reduced TLR4 expression and macrophage infiltration in atherosclerotic plaques. Curcumin also reduced aortic interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) expression, nuclear factor-κB (NF-κB) activity, and plasma IL-1β, TNF-α, soluble VCAM-1 and ICAM-1 levels. In addition, aortic sinus sections revealed that curcumin treatment reduced the extent of atherosclerotic lesions and inhibited atherosclerosis development. In vitro, curcumin inhibited NF-κB activation in macrophages and reduced TLR4 expression induced by lipopolysaccharide. Our results indicate that curcumin protects against atherosclerosis at least partially by inhibiting TLR4 expression and its related inflammatory reaction.
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