1256 CIGARETTE SMOKING IS ASSOCIATED WITH ADVANCED RENAL CELL CARCINOMA

You have accessJournal of UrologyKidney Cancer: Localized1 Apr 20111256 CIGARETTE SMOKING IS ASSOCIATED WITH ADVANCED RENAL CELL CARCINOMA Matvey Tsivian, Daniel Moreira, Jorge Caso, Vladimir Mouraviev, and Thomas Polascik Matvey TsivianMatvey Tsivian Durham, NC More articles by this author , Daniel MoreiraDaniel Moreira Durham, NC More articles by this author , Jorge CasoJorge Caso Durham, NC More articles by this author , Vladimir MouravievVladimir Mouraviev Durham, NC More articles by this author , and Thomas PolascikThomas Polascik Durham, NC More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.941AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Cigarette smoking is a recognized risk factor for renal cell carcinoma (RCC) but little data is available on the association between smoking and RCC biology. Herein we investigated the association between cigarette smoking and RCC stage in a large contemporary multiethnic surgical cohort. METHODS Retrospective review of demographic, clinical and pathological data of patients undergoing surgery for RCC between 2000–2009. Advanced RCC was defined as metastatic disease, pathological stage – and/or lymph node involvement. Self-reported smoking history included smoking status, duration, intensity, cumulative exposure and cessation. Patient and tumor characteristics were compared between the groups by univariate and multivariate analyses. RESULTS Of the 845 eligible patients, 19.4% and 29.1% were current and former smokers; 207 (24.5%) patients had advanced disease. In both univariate and multivariate analyses, smoking was consistently associated with advanced RCC and cessation reversed the risk. Current and former smokers had a 1.5 and 1.6-fold increased odds of advanced disease. Heavier smoking (longer duration and exposure) was associated with increased risk of advanced RCC. Durable cessation reduced the odds of advanced disease by approximately 9% per smoking-free decade. CONCLUSIONS Cigarette smoking is an independent risk factor for advanced RCC. Heavier smoking increases the likelihood of advanced disease with a dose-dependent effect. Durable smoking cessation attenuated the risk of advanced disease. Given that cigarette smoking is among the few modifiable risk factors for RCC, our results reinforce the importance of smoking cessation and encourage further investigation of the association between smoking and RCC biology. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e502 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Matvey Tsivian Durham, NC More articles by this author Daniel Moreira Durham, NC More articles by this author Jorge Caso Durham, NC More articles by this author Vladimir Mouraviev Durham, NC More articles by this author Thomas Polascik Durham, NC More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...