A new on-chip whole blood/plasma separator driven by asymmetric capillary forces

微通道 毛细管作用 分离器(采油) 等离子体 超亲水性 微流控 全血 材料科学 血浆 纳米技术 色谱法 实验室晶片 化学 生物医学工程 接触角 复合材料 外科 医学 生物化学 物理 量子力学 热力学
作者
Kang Kug Lee,Chong H. Ahn
出处
期刊:Lab on a Chip [Royal Society of Chemistry]
卷期号:13 (16): 3261-3261 被引量:52
标识
DOI:10.1039/c3lc50370d
摘要

A new on-chip whole blood/plasma separator driven by asymmetric capillary forces, which are produced through a microchannel with sprayed nanobead multilayers, has been designed, fabricated and fully characterized. The silica nanobead multilayers revealing as superhydrophilic surfaces have been fabricated using a spray layer-by-layer (LbL) nano-assembly method. This new on-chip blood plasma separator has been targeted for a sample-to-answer (S-to-A) microfluidic lab-on-a-chip (LOC) toward point-of-care clinical testing (POCT). Effective plasma separation from undiluted whole blood was achieved through the microchannel which was composed of asymmetric superhydrophilic surfaces with a 10 mm hydrophobic patch. Blood cells were continuously accumulated over the hydrophobic patch while the blood plasma was able to flow over the patch. Therefore, the blood plasma was successfully separated from the whole blood throughout the accumulated blood cells which worked as a so-called 'self-built-in blood cell microfilter'. The separated plasma was approximately 102 nL from a single drop of 3 μL whole blood within 10 min, which is very suitable for single-use disposable POCT devices.

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