细胞凋亡
生物
细胞生物学
T细胞
T细胞受体
细胞生长
免疫系统
分子生物学
免疫学
生物化学
作者
Nam-Doo Hong,Nisha H. Kabra,Shu-Ching Hsieh,Dragana Cado,Astar Winoto
出处
期刊:Journal of Immunology
[The American Association of Immunologists]
日期:1999-08-15
卷期号:163 (4): 1888-1893
被引量:20
标识
DOI:10.4049/jimmunol.163.4.1888
摘要
Abstract The Dad1 protein has been shown to play a role in prevention of apoptosis in certain cell types. Dad1 is also a subunit of the oligosaccharyltransferase enzyme complex that initiates N-linked glycosylation. It is encoded by a gene located adjacent to the TCR α and δ genes on mouse chromosome 14. We have investigated the role of Dad1 during T cell development and activation. We observe that endogenous Dad1 levels are modulated during T cell development to reach maximal expression in mature thymocytes. Transgenic mice that overexpress Dad1 in both the thymus and peripheral immune system have been generated. Apoptosis of thymocytes from such mice is largely unaffected, but peripheral T cells display hyperproliferation in response to stimuli. Therefore, the linkage between the TCR and Dad1 genes may have important consequences for T cell function.
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