医学
累积发病率
造血干细胞移植
调理疗法
内科学
养生
单中心
移植
急性淋巴细胞白血病
淋巴细胞白血病
入射(几何)
白血病
外科
肿瘤科
光学
物理
作者
Xiaoyan Zhao,Xuan Lu,Liang Tang,Han Yan,Wenlan Chen,Wei Shi,Zhaodong Zhong,Yong You,Linghui Xia,Yu Hu,Huafang Wang
标识
DOI:10.1080/10428194.2020.1789621
摘要
This study aimed to retrospectively evaluate the outcomes of adult patients with high-risk acute lymphoblastic leukemia (ALL) who received allogeneic hematopoietic stem cell transplantation (allo-HSCT) with either total marrow and lymphoid irradiation (TMLI)-containing or non-TMLI conditioning regimen. Seventy adult patients with high-risk ALL who received allo-HSCT were enrolled in this study and divided into two groups based on the conditioning regimen type (TMLI group: n = 29 and non-TMLI group: n = 41). We noted significant statistical differences in the 1-year estimated cumulative incidence of relapse (25% vs. 46.5%, p = 0.018), the 1-year estimated overall survival (73.1% vs. 52.6%, p = 0.033) and disease-free survival (65.2% vs. 48.2%, p = 0.026) but found no considerable difference in transplant-related mortality (12% vs. 13.4%, p = 0.619) between patients in the TMLI and non-TMLI groups. The TMLI-containing regimen is safe and alternative for patients with high-risk ALL undergoing allo-HSCT.
科研通智能强力驱动
Strongly Powered by AbleSci AI