[Significance of Detecting Serum Complement C3 and C4 in Patients with Multiple Myeloma].

To investigate the significance of detecting serum complement C3 and C4 in patients with multiple myeloma (MM) and to explore its correlation with myeloma bone disease (MBD).The levels of serum complement C3 and C4 in 69 MM patients and 30 healthy people were examined by scatter nephelometry. The bone density of L1-4 vertebral body, bilateral femoral neck and bilateral hip joints were measured by dual energy bone density meter (DXA).The levels of serum complement C3 and C4 in MM patients significantly increased in comparison with that in healthy people (P＜0.01). The patients in advanced clinical stage exhibited a higher levels of C3 and C4 than those in stable stage (P＜0.01). In addition, the patients with grade C of MBD had a higher levels of serum complement C3 and C4 than those in patients with grade A and B of MBD (P＜0.01). The levels of serum complement C3 and C4 in MM patients negatively correlated with bone density in L1-4 vertebral body, bilateral femoral necks and hip joints. The correlation coefficients were r=-0.938, r=-0.659, r=-0.745, r=-0.748, r=-0.596 in complement C3 and r=-0.908, r=-0.623, r=-0.710, r=-0.714, r=-0.595 in complement C4, respectively.The levels of complement C3 and C4 positively correlate with the severity of bone disease and bone density in MM patients, which suggests that complement C3 and C4 plays important roles in the development of MBD. The levels of serum C3 and C4 may be the sensitive biomarkers of MBD.血清补体C3、C4在多发性骨髓瘤患者中检测的意义.研究血清补体C3、C4在多发性骨髓瘤（MM）患者中的检测意义，并探讨其与骨髓瘤骨病（MBD）的相关性.采用散射比浊法定量分析69例初诊MM患者以及30例健康体检者血清补体C3、C4水平；采用双能骨密度仪（DXA）测量69例初诊MM患者以及30例健康体检者的正位L1-4椎体、双侧股骨颈、双侧髋关节的骨密度值.MM患者组血清补体C3、C4水平明显高于对照者（P＜0.01）；ISS临床分期中进展期患者的血清补体C3、C4水平明显高于稳定期患者（P＜0.01）；在不同MBD分组中，分级C级的补体C3、C4水平明显高于A级和B级（P＜0.01）；MM患者血清补体C3、C4表达水平与其L1-4椎体、左右股骨颈和左右髋关节整体的骨密度呈负相关，相关系数分别为r=-0.938，r=-0.659，r=-0.745，r= -0.748，r=-0.596和r=-0.908， r=-0.623，r=-0.710，r=-0.714，r=-0.595.MM患者血清中补体C3、C4水平升高，与MM患者骨病严重程度及骨密度相关，这提示，补体C3、C4在MBD发生发展中可能发挥重要作用，血清中C3、C4水平可能是MBD的敏感生物标志物.