MICROWAVE-ASSISTED SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF SOME PYRAZOLE DERIVATIVES

Reaction of 3-(1H-indol-3-yl)-(1-methyl/phenyl)prop-2-en-1-one (Chalcones) was carried out with hydrazine hydrate, phenyl hydrazine, isoniazide, nicotinic hydrazide and thiosemicarbezide (corresponding hydrazides) in ethanol containing a few drops of glacial acetic acid under microwave irradiation giving 1Hindol containing pyrazole derivatives.The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR and 1 H NMR. All the synthesized compounds have been screened for their antibacterial and antifungal activities.