The Novel Medical Thermoresponsive Hydrogel Derived from Chitosan

Background: Chitosan thermoresponsive hydrogel is non-covalent crosslinked intelligent hydrogel. The compositions of the hydrogel determine its gelling property associated with particular structure-interaction effects. Simple and mild preparations as well as desirable bioactivities allow chitosan thermoresponsive hydrogels extensively applied in drug delivery and tissue engineering, especially the exciting proceeding in enzyme-free cell harvest and vascular embolic agent. Objective: This paper reviewed the classification of chitosan thermoresponsive hydrogels based on different components, emphasizing their gelling capacities, mechanism and applications in biomedical areas. Keywords: Chitosan, thermoresponsive hydrogel, sol-gel reversible, drug delivery, tissue engineering, cell culture, wound dressing, embolic agent.