Factor VIII Products and Inhibitor Development in Severe Hemophilia A
医学
抗体
内科学
因子IX
免疫学
作者
Samantha C. Gouw,Johanna G. van der Bom,Rolf Ljung,Carmen Escuriola,Ana Rosa Cid,Ségolène Claeyssens‐Donadel,Chris Van Geet,Gili Kenet,Anne Mäkipernaa,Angelo Claudio Molinari,W. Muntean,Rainer Kobelt,George E. Rivard,Elena Santagostino,Angela Thomas,H. Marijke van den Berg
Recombinant and plasma-derived factor VIII products conferred similar risks of inhibitor development, and the content of von Willebrand factor in the products and switching among products were not associated with the risk of inhibitor development. Second-generation full-length recombinant products were associated with an increased risk, as compared with third-generation products. (Funded by Bayer Healthcare and Baxter BioScience.).
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(2025-6-4)
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