细胞生物学
内生
血管平滑肌
钙化
化学
血管组织
XBP1型
生物
信号转导
内科学
血管
信使核糖核酸
下调和上调
内分泌学
主动脉
内皮
生物化学
血管疾病
循环系统
癌症研究
作者
Liu Yang,Rongbo Dai,Hao Wu,Zeyu Cai,Nan Xie,Xu Zhang,Yicong Shen,Ze Gong,Yiting Jia,Fang Yu,Ying Zhao,Pinglan Lin,Chaoyang Ye,Yanhua Hu,Yi Fu,Qingbo Xu,Zhiqing Li,Wei Kong
出处
期刊:Circulation Research
[Lippincott Williams & Wilkins]
日期:2021-12-06
卷期号:130 (2): 213-229
被引量:83
标识
DOI:10.1161/circresaha.121.319745
摘要
Our study identified XBP1u as a novel endogenous inhibitor of vascular calcification by counteracting β-catenin and promoting its ubiquitin-proteasomal degradation, which represents a new regulatory pathway of β-catenin and a promising target for vascular calcification treatment.
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