化学
苯并咪唑
广告
组合化学
生物信息学
碳-13核磁共振
分子
体外
质子核磁共振
抗菌活性
立体化学
有机化学
生物化学
细菌
基因
生物
遗传学
作者
Prachi T. Acharya,Zeel A. Bhavsar,Divya J. Jethava,Dhanji P. Rajani,Edwin A. Pithawala,Hitesh Patel
摘要
The anti-microbial, anti-tubercular, anti-malarial, and anti-oxidant properties of a series of benzimidazole hybrid thiosemicarbazide derivatives (7a-o) were investigated in vitro. IR, 1H-NMR, 13C-NMR, and ESI-MS spectra were used to describe and elucidate the synthesized compounds. The majority of the compounds studied have excellent antibacterial and antioxidant properties. In addition, an in silico investigation was conducted. By calculating ADME-Tox descriptors, all freshly synthesised molecules were shown to have outstanding pharmacokinetic properties, indicating that these derivatives could be used as a basis for the development of some novel active drugs. A SAR (structure-activity relationship) was also briefly described. This article is protected by copyright. All rights reserved.
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