Asymmetric Induction in Radical Cyclization Leading to β-Lactams: Formal Synthesis of (+)-PS-5

All articles of this category Tributyltin hydride-mediated radical cyclization of N -[2,2-bis(phenylthio)ethenyl]-α-bromoalkanamides bearing ( S )-1-phenylethyl group on the nitrogen atom gave (4 S )-4-bis(phenylthio)-methyl-2-azetidinones as major products. The method was applied to the synthesis of a chiral precursor of carbapenem antibiotic (+)-PS-5.