微透析
细胞外
氨基酸
脊髓
脊髓损伤
兴奋性氨基酸转运体
谷氨酸受体
细胞外液
兴奋性突触后电位
抑制性突触后电位
中枢神经系统
麻醉
化学
医学
药理学
生物化学
生物
内科学
神经科学
受体
作者
S. Scott Panter,Sabrina W. Yum,Alan I. Faden
标识
DOI:10.1002/ana.410270115
摘要
Abstract It has recently been demonstrated that N ‐methyl‐D‐aspartate antagonists limit tissue damage after spinal cord trauma, implicating excitatory amino acids in the secondary injury response. To determine whether spinal cord trauma alters the concentrations of extracellular amino acids, microdialysis was conducted in spinal cord during and after administration of impact trauma. Extracellular concentrations of excitatory, inhibitory, and nontransmitter amino acids were elevated after trauma, with the degree of increase related to severity of injury. Moderate trauma resulted in an immediate but transient increase (200‐400%) in the extracellular levels of all amino acids measured. Severe trauma produced a more prolonged and significant increase (400‐630%) in the concentrations of extracellular amino acids, including aspartate and glutamate. These results are consistent with the hypothesis that excitatory amino acids may contribute to delayed tissue injury after central nervous system trauma.
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