医学
冲程(发动机)
随机对照试验
风险因素
物理疗法
急诊医学
生活质量(医疗保健)
随机化
临床试验
儿科
重症监护医学
内科学
机械工程
工程类
护理部
作者
Jacques Joubert,Stephen M. Davis,Graeme J. Hankey,Christopher R Levi,John Olver,Gerard Bryan Gonzales,Geoffrey A. Donnan
摘要
The majority of strokes, both ischaemic and haemorrhagic, are attributable to a relatively small number of risk factors which are readily manageable in primary care setting. Implementation of best-practice recommendations for risk factor management is calculated to reduce stroke recurrence by around 80%. However, risk factor management in stroke survivors has generally been poor at primary care level. A model of care that supports long-term effective risk factor management is needed.To determine whether the model of Integrated Care for the Reduction of Recurrent Stroke (ICARUSS) will, through promotion of implementation of best-practice recommendations for risk factor management reduce the combined incidence of stroke, myocardial infarction and vascular death in patients with recent stroke or transient ischaemic attack (TIA) of the brain or eye.A prospective, Australian, multicentre, randomized controlled trial.Academic stroke units in Melbourne, Perth and the John Hunter Hospital, New South Wales.1000 stroke survivors recruited as from March 2007 with a recent (<3 months) stroke (ischaemic or haemorrhagic) or a TIA (brain or eye).Randomization and data collection are performed by means of a central computer generated telephone system (IVRS).Exposure to the ICARUSS model of integrated care or usual care.The composite of stroke, MI or death from any vascular cause, whichever occurs first.Risk factor management in the community, depression, quality of life, disability and dementia.With 1000 patients followed up for a median of one-year, with a recurrence rate of 7-10% per year in patients exposed to usual care, the study will have at least 80% power to detect a significant reduction in primary end-pointsThe ICARUSS study aims to recruit and follow up patients between 2007 and 2013 and demonstrate the effectiveness of exposure to the ICARUSS model in stroke survivors to reduce recurrent stroke or vascular events and promote the implementation of best practice risk factor management at primary care level.
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