Effect of PQS on the cell immune system of the patients with CPHD

Aim To investigate the effect of Panax Quinquefolium Saponin (PQS) on the cell immune system of the patients with Chronic Pulmonary Heart Disease (CPHD) and then to find out the relationship between the immune system and the mechanism of CPHD. Methods The T lymph subgroup and NK (CD3 -/CD16+56 +) cells in patients’ peripheral blood were detected by flow cytometry, and the expression of IL 2, IFNγ mRNA were analyzed by RT PCR. Results CD3 +, CD4 + and CD4/CD8 in patients with CPHD were significantly lower than those in the control, while CD8 + higher ( P 0 01). CD3 +, CD4 +, CD4/CD8 and NK (CD3 -/CD16+56 +) cells in the patients were increased after PQS treated, and CD3 +, CD4 + were significantly different from pre treated ( P 0 05), while CD8 + cells were significantly lower than those in pre treated ( P 0 05). PQS stimulated the expression of IL 2, IFNγ mRNA excreted by T lymph cells. Conclusions The results showed that PQS can improve the cell immune function, especially in patients with CPHD whose immune function are low.