Cerebral Gigantism in Childhood

THE 5 children described below had an illness characterized by excessively rapid growth, acromegalic features and a nonprogressive cerebral disorder with mental retardation. The pattern of clinical findings failed to conform to any of the recognized causes of tall stature. The remarkable similarity among the cases justifies their grouping as a syndrome that, to our knowledge, has not previously been described.Case ReportsCase 1. A 10–2/12-year-old boy (M.G.H. 1199268) was referred for evaluation of his large body size, slow mental development and hyperactivity. As shown in Figures 1 and 2, he grew and gained at an unusually rapid rate during the . . .