Influence of Rhodiola on Expression of Fasl and Performing in Mice Spleen

Objective:The purpose of the test is to find the effects of Traditional Medicine Rhodiola on immune level in mice and probe into the effects of Rhodiola on immune mechanism system so as to offer scientific basis for clinic application of Traditional Medicine Rhodiola. Methods: This experiment uses Rhodiola as the experimental medicine,and mice as the experimental animals. It chooses pure Balb/c mice and Traditional Medicine Rhodiola of different doses were fed to mice continuously in force. After several days,the samples in each group were collected for testing. It demonstrated through the index of protein expression that the effect of Traditional Medicine Rhodiola on the mice. Results: The results showed as follows: experimental group could significantly increase the expression of Fasl and Perforin in mice splenetic compared to the contrast group (P0.01); it showed that Rhodiola could significantly increase cellular immune function of mice; it also showed that Rhodiola could promote the nonspecific immune function of mice; These were enhanced significantly when the immunology function of mice was inhibited by Cy (P0.01); it showed that the Rhodiola enhanced the killing activity of the lymphocytes obviously-exhibiting as the expression of the two (Fasl and perforin) index increasing obviously. Conclusions: These experiments indicated that Traditional Medicine Rhodiola was able to activate immune function of mice and enhance Fasl and perforin to express in mice spleen.These tests will provide sufficient scientific basis for clinic application of Traditional Medicine Rhodiola.