Relationship between abdominal obesity and left ventricular weight/function

Objective To observe the relationship between abdominal obesity and left ventricular weight/function.Methods A total of 495 patients [265 males,mean age (55±12) years] with hypertension (139),diabetes (65),metabolic syndrome (285),diabetes complicated with hypertension (11) were enrolled in this study.Visceral adipose area (VA) ,the subcutaneous adipose (SA),the total abdominal adipose (TA) were measured by computerized tomography (CT) and left ventricular weight and function were obtained by echocardiography.Patients were divided into three groups1according to the VA (Ⅰ.VA75 cm~2,n=173,Ⅱ.VA75 and110cm~2,n=153,Ⅲ.VA≥110cm~2,n=169).Results Left ventricular mass (LVM) and LVM index (LVMI) increased and LVEF and E/A decreased in proportion to increasing VA.Left ventrieular hypertrophy (LVH) rate was significantly higher in group Ⅱ and Ⅲ compared to group Ⅰ and LVEF was significantly reduced in group Ⅲ compared to group Ⅰ and Ⅱ. There are significant correlation between LVMI and VA、SA、TA as well as between LVEF and VA after adjusting gender,age and blood pressure.Logistic regression analysis showed that VA is an independent predictor for LVH.Conclusion The abdominal adipose accumulation is closely related to the left ventricular weight and function.