CRISPR and new genetic-engineering techniques: emerging challenges to strategic stability and nonproliferation

This article explores the potential for new biotechnologically enabled weapons to compete with nuclear weapons in the context of strategic stability, assesses how such new technologies may affect assumptions in traditional strategic-stability models when applied to such scenarios, and how changing capabilities and adversaries may shape approaches to nonproliferation, verification, and monitoring. Among the most recent additions to the genome-editing arsenal is CRISPR (clustered regularly interspaced short palindromic repeats), a bacteria-derived system that is among the simplest genome-editing tools. The CRISPR-Cas9 system—and emerging variants of the system—enables unprecedented control and ease when editing the genome. With parallels to remote “command and control” of the genome, this aspect makes the technology different from earlier gene-editing methods. This article furthers the scholarly work on the biosecurity implications of CRISPR, gene editing, and broader issues of biotechnology by addressing these emerging life-science technologies in the context of nuclear strategic stability and implications for balance of power, nonproliferation, and international security.