Metabolic status and brain health: the relationship between the metabolic score for insulin resistance and cognitive function in older adults

Elevated METS-IR is independently associated with cognitive decline in older adults and shows a threshold effect. Its accessibility and stable discriminative ability support its potential as a supplementary tool for risk stratification. Future longitudinal studies are needed to verify the causal relationship and explore the feasibility of improving cognitive function through metabolic interventions. This study provides new evidence for the association between metabolic health and brain health, offering scientific basis for early screening and intervention strategies for high-risk populations.