A foam cell-targeted lipophagy restoration strategy stabilizes vulnerable atherosclerotic plaques

studies demonstrate that OPN-HMCN@MLT not only suppresses plaque progression but also promotes regression of established lesions, accompanied by reduced foam cell accumulation, improved lipid metabolic reprogramming, and enhanced plaque stability, without detectable systemic toxicity. By functionally coupling targeted lipophagy restoration with supportive molecular imaging at the pathological substrate level, this work establishes a therapy-centered nanomedicine strategy that enables precision intervention and longitudinal monitoring, offering strong translational potential for the management of advanced atherosclerosis.