Conservation agriculture is a farming system based on three main principles: reduced soil disturbance, permanent organic cover, and crop rotation. It is widely promoted as a sustainable solution to reduce soil degradation, restore and maintain soil health, enhance climate resilience in crop production, and mitigate greenhouse gas emissions. However, its universal applicability across diverse biophysical and socioeconomic contexts remains highly debated due to inconsistent agronomic performance. Using a global meta-analysis, we evaluated the effect of conservation practices under different climate and soil conditions on soil properties that regulate soil-water movement, storage, accessibility to crops, soil aeration, and crop yield. Performances of five conservation agricultural practices, namely no-till without residue (NT), reduced tillage without residue (RT), no-till with residue (NT+RR), reduced tillage with residue (RT+RR), and conventional tillage with residue retention (CT+RR), were compared with conventional tillage without residue (CT) based on observations from 328 studies across 361 experimental sites.Mean yield responses to conservation practices ranged from a reduction of 6.3% (p=0.02) for NT to no significant yield effects (+3.4%; p=0.29) under CT+RR as compared to CT. Increasing tillage intensity (from NT to CT) and residue retention were associated with higher crop yields (p=0.046). Yield outcomes varied with climatic and soil conditions. In semi-dry climates (aridity index: 0.3-0.65) NT increased yields by 16.3% (p=0.004), likely related to changes in infiltration (+24%, p=0.12), although the mean change was not significant for the latter. In contrast, NT reduced yields in humid climates (-7.2%, p