Detection methods and clinical significance of chimerism after hematopoieticstem cell transplation

Sequential monitoring of chimerism after hematopoietic stem cell transplantation is important for disease prognosis, improving transplantation success rate, and reducing relapses of the original diseases. The application of molecular genetic markers in combination with quantitative PCR to the assessment of chimerism,in particularly the dynamic quantitative analysis of lineage-specific chimerism, can provide important guidance for clinical practice. Key words: Hematopoietic stem cell transplation; Chimera; Polymerase chain reaction