Elastin Biomaterials in Dermal Repair

Novel elastin-based scaffolds have demonstrated efficacy. Elastin-based skin substitutes improve clinical outcomes in burn wounds when transplanted beneath split-thickness skin grafts. Functionalized elastin recombinamers enhance in vitro endothelial and fibroblast cell proliferation as well as in vivo angiogenesis. Recombinant human tropoelastin promotes early angiogenesis and harmonizes with the therapeutic benefits of existing dermal dressings. Tropoelastin improves wound healing and promotes de novo elastin synthesis. Tropoelastin-based constructs can be polymerized using a range of methods, including photocrosslinking, chemical crosslinking and heat to enhance healing. Wound healing has historically relied on endogenous processes, but engineered materials are increasingly being used to assist tissue repair. Elastin is an essential functional component of the dermal extracellular matrix and is an important part of skin wound repair that encompasses an elastic dermis. Advances in modern technology have better elucidated the specific signaling factors and cells that contribute to the physiological process and have led to new developments in wound care technology. We review elastin-based materials that are used to encourage wound repair. Elastin-related biomaterials, particularly those based on tropoelastin, are particularly promising because tropoelastin is assembled to make elastin. We present insights into the roles of elastin-related biomaterials and their associated in vitro and in vivo benefits on wound healing. Wound healing has historically relied on endogenous processes, but engineered materials are increasingly being used to assist tissue repair. Elastin is an essential functional component of the dermal extracellular matrix and is an important part of skin wound repair that encompasses an elastic dermis. Advances in modern technology have better elucidated the specific signaling factors and cells that contribute to the physiological process and have led to new developments in wound care technology. We review elastin-based materials that are used to encourage wound repair. Elastin-related biomaterials, particularly those based on tropoelastin, are particularly promising because tropoelastin is assembled to make elastin. We present insights into the roles of elastin-related biomaterials and their associated in vitro and in vivo benefits on wound healing. a proangiogenic factor that is important in the early stages of wound healing. a material that interacts with biological systems. an abundant protein in the ECM that is responsible for conferring elasticity to its resident tissue. the elastin fiber is an elastic fiber that comprises a range of macromolecules, particularly elastin and microfibrillar proteins. engineered constructs comprising a recurring oligopeptide sequence located in a subsequence of tropoelastin. an ELP engineered using recombinant DNA technology with tunable physicochemical properties. a 3D matrix containing proteins such as collagen, elastin, and glycoproteins to provide structural and biochemical support to the cells. gelatin derivatized with methacrylol groups to allow photoactivated crosslinking. an elastin–collagen acellular skin substitute derived from human skin. a tropoelastin material produced using heat. a thickened, raised, and erythematous scar caused by excessive collagen deposition in the wound area. an acellular collagen and glycosaminoglycan dermal substitute. a growth factor involved in wound healing that is present at high levels during re-epithelialization. the temperature above which tropoelastin molecules aggregate and initiate the coacervation process. an acellular bovine-based collagen I, III, V, and elastin hydrolysate dermal substitute. a photocrosslinkable bioelastomer consisting of recombinant human tropoelastin (rhTE). regulates cell growth and division. an amino acid sequence derived from fibronectin that mediates binding to endothelial cells via integrin α4β1 and promotes endothelial cell adhesion and migration. a tripeptide amino acid sequence that mediates the binding of proteins to cell surfaces and therefore promotes cell attachment/adhesion. a skin graft containing the epidermis and part of the dermis. a protein with structural similarities to EGF and that also acts on EGF receptors. involved in various cell signaling processes and can either induce or inhibit angiogenesis by increasing proangiogenic signals or antiangiogenic signals. soluble protein precursor of elastin. a proangiogenic signaling molecule that is released in response to hypoxia.