化学
催化作用
对映选择合成
氢化物
铱
小学(天文学)
组合化学
羧酸
有机化学
金属
天文
物理
作者
Achim Link,Yujing Zhou,Stephen L. Buchwald
出处
期刊:Organic Letters
[American Chemical Society]
日期:2020-07-06
卷期号:22 (14): 5666-5670
被引量:14
标识
DOI:10.1021/acs.orglett.0c02064
摘要
The direct enantioselective copper hydride (CuH)-catalyzed synthesis of β-chiral amides from α,β-unsaturated carboxylic acids and secondary amines under mild reaction conditions is reported. The method utilizes readily accessible carboxylic acids and tolerates a variety of functional groups in the β-position including several heteroarenes. A subsequent iridium-catalyzed reduction to γ-chiral amines can be performed in the same flask without purification of the intermediate amides.
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