Comparative Study of Tadalafil And Tamsulosin in Benign Hyperplasia of Prostate For Lower Urinary Tract Symptoms (LUTS)

Objectives: Tadalafil has been approved by the U.S. Food and Drug Administration in 2011 to treat the signs and symptoms of Lower Urinary Tract symptoms (LUTS) due to benign hyperplasia of prostate(BHP).Tamsulosin is being used to treat LUTS due to BHP.Tadalafilacts by inhibiting phosphodiesterase-5 (PDE5) thereby improving the erectile function by increasing the amount of cyclic guanosine monophosphate in the smooth muscle of the corpus cavernosa.This study aims for the comparison of tadalfil with other established drug tamsulosin in Indian population Methods: A total of 100 patient presenting with lower urinary tract symptoms( LUTS) due to BPH were selected and randomized with card method to receive either 5mg tadalafil daily or 0.4 mg tamsulosin daily.The parameters recorded includes Q max, PVR(post void residual urine), IPSS(International prostate symptom score), IIEF(International index of erectile function-erectile function) at the start of study and at end of 12 weeks.Data was analysed using Student T Test.Results: The groups were identical for statistical analysis.LUTS was improved by both tamsulosin and tadalafil.But tamsulosin is slightly more effective than tadalafil but notstatistically significant ( p > 0.05) in relieving LUTS.Only tadalafil significantly improved erectile dysfunction (p<0.05). Conclusion: Tadalafil is effective in treating the both LUTS and erectile dysfunction.Comparative Study of Tadalafil and Tamsulosin in Benign Hyperplasia of Prostate for