剪接体
RNA剪接
snRNP公司
细胞生物学
化学
小剪接体
计算生物学
核糖核酸
遗传学
生物
基因
作者
Ruixue Wan,Chuangye Yan,Rui Bai,Guangli Huang,Yigong Shi
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2016-08-26
卷期号:353 (6302): 895-904
被引量:171
标识
DOI:10.1126/science.aag2235
摘要
How spliceosomes make the first cut In eukaryotes, transcribed precursor mRNA includes noncoding sequences that must be spliced out. This is done by the spliceosome, a dynamic complex in which five small nuclear RNAs and several proteins go through a series of ordered interactions and conformational rearrangements to achieve splicing. Two protein structures provide a look at the first catalytic step in the pathway. Yan et al. report the structure of the activated spliceosome (the B act complex) at 3.5 Å resolution, revealing how latency is maintained even though the complex is mostly primed for catalysis. Wan et al. report the structure of the catalytic step 1 spliceosome (the C complex) at 3.4 Å resolution; this complex forms after the first step of the splicing reaction. Science , this issue pp. 904 and 895
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