寡肽酶
脯氨酰内肽酶
药理学
脑啡肽酶
神经科学
生物
计算生物学
生物信息学
医学
生物化学
酶
作者
Katerina Babkova,Jan Korabecny,Ondrej Soukup,Eugenie Nepovimova,Daniel Jun,Kamil Kuca
出处
期刊:Future Medicinal Chemistry
[Newlands Press Ltd]
日期:2017-06-01
卷期号:9 (10): 1015-1038
被引量:43
标识
DOI:10.4155/fmc-2017-0030
摘要
Prolyl oligopeptidase (POP), also called prolyl endopeptidase, is a cytosolic enzyme investigated by several research groups. It has been proposed to play an important role in physiological processes such as modulation of the levels of several neuronal peptides and hormones containing a proline residue. Due to its proteolytic activity and physiological role in cell signaling pathways, inhibition of POP offers an emerging approach for the treatment of Alzheimer's and Parkinson's diseases as well as other diseases related to cognitive impairment. Furthermore, it may also represent an interesting target for treatment of neuropsychiatric disorders, and as an antiangiogenesis or antineoplastic agent. In this review paper, we summarized naturally occurring POP inhibitors together with peptide-like inhibitors and their biological effects. Some of them have shown promising results and interesting pharmacological profiles. However, to date, there is no POP inhibitor available on the market although several clinical trials have been undertaken.
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