转录因子
生物
祖细胞
背景(考古学)
造血
基因
染色质
细胞生物学
谱系(遗传)
遗传学
干细胞
古生物学
作者
Boyoung Shin,Wen Zhou,Jue Wang,Fan Gao,Ellen V. Rothenberg
标识
DOI:10.1101/2022.11.18.517146
摘要
Abstract Runx factors are essential for lineage specification of various hematopoietic cells, including T lymphocytes. However, they regulate context-specific genes and occupy distinct genomic regions in different cell types. Here, we show that dynamic Runx binding shifts in early T-cell development are mostly not restricted by local chromatin state but regulated by Runx dosage and functional partners. Runx co-factors compete to recruit a limited pool of Runx factors in early T-progenitors, and a modest increase in Runx protein availability at pre-commitment stages causes premature Runx occupancy at post-commitment binding sites. This results in striking T-lineage developmental acceleration by selectively activating T-identity and innate lymphoid cell programs. These are collectively regulated by Runx together with other, Runx-induced transcription factors that co-occupy Runx target genes and propagate gene network changes.
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