光热治疗
光热效应
材料科学
癌症研究
纳米技术
生物医学工程
医学
生物物理学
生物
作者
Xiaolei Zhang,Ziying Wang,Yangsai Lyu,Jia Li,Kun Song,Ningning Xing,Dickon H. L. Ng
标识
DOI:10.1016/j.jiec.2022.09.008
摘要
Near-infrared (NIR) light-powered nanomotors with active motion have attracted extensive attention in the chemo-photothermal therapy of cancer. However, there are also some limitations such as complicated synthesis process, low permeability of drugs and viscous physiological environment. Herein, we developed a facile route to synthesize novel NIR light-powered DOX/Au-m-HTAS nanomotor based on natural halloysite (HNTs) for active chemo-photothermal therapy. Such nanomotor exhibited NIR light controlled on/off motion with a maximum speed of 64.5 μm/s. Owing to the synergetic NIR light-powered motion and chemo-photothermal therapy, DOX/Au-m-HTAS nanomotor could effectively adhere tumor cells, leading to deeper cell penetration, higher cellular uptake, and better ablation of tumor cells. Meanwhile, DOX/Au-m-HTAS nanomotors also had enhanced ability for CT imaging of local tumor, demonstrating the enhanced anticancer efficiency. This strategy provided a new insight into the chemo-photothermal synergistic therapy of tumors.
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