氧氟沙星
化学
核化学
检出限
莫西沙星
环丙沙星
微生物学
材料科学
色谱法
抗生素
生物化学
生物
作者
Ruchi Aggarwal,Anjali Kumari Garg,Vinit Kumar,Harshita Jonwal,Shruti Sethi,Srushti Gadiyaram,Sumit Kumar Sonkar,Amit Kumar Sonker,Gunnar Westman
出处
期刊:ACS applied nano materials
[American Chemical Society]
日期:2023-04-18
卷期号:6 (8): 6518-6527
被引量:5
标识
DOI:10.1021/acsanm.2c05526
摘要
A two-step viable synthetic approach for quick and energy-efficient acid-based charring is described here to fabricate self-passivated fluorescent water-soluble CD (wsCD) from sustainable microcrystalline cellulose (MCC) materials. The aqueous solution of wsCD exhibits blue emission under UV-light illumination and shows a fluorescence quantum yield of ∼6%. The wsCD are used here for the selective sensing of ofloxacin (OFLX) from among the four tested antibiotics of the fluoroquinolone class, namely, ciprofloxacin (CPLX), ofloxacin (OFLX), levofloxacin (LVLX), and moxifloxacin (MXLX) based on the simpler fluorescence quenching experiment with a detection limit of ∼0.025 ppm. The plausible mechanism for the selective sensing of OFLX has been proposed based on a detailed analysis of absorbance and time-resolved photoluminescence spectroscopy which indicates the involvement of the inner-filter effect (IFE). Antimicrobial studies of wsCD were conducted on two bacterial strains (Escherichia coli and Staphylococcus aureus) and two fungal strains (Aspergillus niger and Penicillium chrysogenum), where wsCD did not show any toxic effects up to the concentration of 1 mg/mL, hence supporting their biocompatible behavior. Further, an antibiosis study involving the combination of the antibiotic and antifungal agents with wsCD against the growth of the same bacterial and fungal strains was conducted, where wsCD showed mild antifungal activity.
科研通智能强力驱动
Strongly Powered by AbleSci AI