Animal models to study cognitive impairment of chronic kidney disease

认知 肾脏疾病 疾病 医学 情感(语言学) 认知功能衰退 执行职能 心理学 临床心理学 精神科 痴呆 病理 内科学 沟通
作者
Pedro Henrique Imenez Silva,Marion Pépin,Andreja Figurek,Eugenio Gutiérrez‐Jiménez,Mickaël Bobot,Anna Iervolino,Francesco Mattace‐Raso,Ewout J. Hoorn,Matthew A. Bailey,Lucie Hénaut,Rikke Nielsen,Sebastian Frische,Francesco Trepiccione,Gaye Hafez,Hande Özge Altunkaynak,Nicole Endlich,Robert J. Unwin,Giovambattista Capasso,Vesna Pešić,Ziad A. Massy,Carsten A. Wagner,Connect Consortium
出处
期刊:American Journal of Physiology-renal Physiology [American Physiological Society]
标识
DOI:10.1152/ajprenal.00338.2023
摘要

Mild cognitive impairment (MCI) is common in people with chronic kidney disease (CKD) and its prevalence increases with progressive loss of kidney function. MCI is characterized by a decline in cognitive performance greater than expected for an individual age and education level but with minimal impairment of instrumental activities of daily living. Deterioration can affect one or several cognitive domains (attention, memory, executive functions, language, and perceptual motor or social cognition). Given the increasing prevalence of kidney disease, more and more people with CKD will also develop MCI causing an enormous disease burden for these individuals, their relatives and society. However, the underlying pathomechanisms are poorly understood and current therapies mostly aim at supporting patients in their daily life. This illustrates the urgent need to elucidate the pathogenesis, and potential therapeutic targets and test novel therapies in appropriate preclinical models. Here, we will outline the necessary criteria for experimental modelling of cognitive disorders in CKD. We discuss the use of mice, rats and zebrafish as model systems and present valuable techniques through which kidney function and cognitive impairment can be assessed in this setting. Our objective is to enable researchers to overcome hurdles and accelerate preclinical research aimed at improving therapy of people with CKD and MCI.

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