Characterization of the Molecular Mechanisms Underlying Lurasidone‐Induced Acute Manic Episodes in Bipolar Depression: A Network Pharmacology and Molecular Docking Approach

This study revealed that lurasidone may regulate the serotonergic synapse signaling pathway by interacting with the identified core targets MAOB, HTR1A, HTR2A, HTR3A, SLC18A2, HTR1B, and HTR7 to induce treatment-emergent mania in people with bipolar depression. Our work provides a theoretical basis for the pharmacology of lurasidone-induced acute mania in bipolar depression and further basic research.