心理学
痴呆
萧条(经济学)
焦虑
临床心理学
精神分裂症(面向对象编程)
双相情感障碍
精神科
认知
精神分裂症谱
医学
精神病
疾病
内科学
经济
宏观经济学
作者
Johanna Seitz‐Holland,Shalaila S. Haas,Nora Penzel,Abraham Reichenberg,Ofer Pasternak
标识
DOI:10.1016/j.neubiorev.2024.105581
摘要
The imaging-based method of brainAGE aims to characterize an individual's vulnerability to age-related brain changes. The present study systematically reviewed brainAGE findings in neuropsychiatric conditions and discussed the potential of brainAGE as a marker for biological age. A systematic PubMed search (from inception to March 6th, 2023) identified 273 articles. The 30 included studies compared brainAGE between neuropsychiatric and healthy groups (n≥50). We presented results qualitatively and adapted a bias risk assessment questionnaire. The imaging modalities, design, and input features varied considerably between studies. While the studies found higher brainAGE in neuropsychiatric conditions (11 mild cognitive impairment/ dementia, 11 schizophrenia spectrum/ other psychotic and bipolar disorder, six depression/ anxiety, two multiple groups), the associations with clinical characteristics were mixed. While brainAGE is sensitive to group differences, limitations include the lack of diverse training samples, multi-modal studies, and external validation. Only a few studies obtained longitudinal data, and all have used algorithms built solely to predict chronological age. These limitations impede the validity of brainAGE as a biological age marker.
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