Chemical constituents of Penicillium ferraniaense GE-7 and their cytotoxicities

Phytochemical investigation on the plant endophytic fungus Penicillium ferraniaense GE-7 led to the isolation of 18 compounds including one new α-pyrone derivative, peniferranige A (1). The structure including the absolute configuration of compound 1 was elucidated by NMR, HRMS, and ECD data. Demethoxyfumitremorgin C (16) and meleagrin (17) possessed moderate activities against the human lung cancer cell line H1975 with IC₅₀ values of 28.52 ± 1.07 and 13.94 ± 1.92 μM, respectively.