Exosome-derived Menin from cancer-associated fibroblasts promotes gastric cancer progression by activating the HSPA6/JNK/JunD pathway and inducing EMT

CAFs can promote GC progression by delivering Menin-containing exosomes, which activates the HSPA6/JNK/JunD pathway and induces EMT. Targeting Menin within CAFs and GC cells and blocking the delivery of Menin by exosomes may provide novel strategies for GC treatment.