Polysorbate 80 surface modified PLGA nanoparticles: an in-vitro evaluation of cellular uptake and cytotoxicity on neuro-2a cells

AIM: evaluation of Cellular Uptake & Cytotoxicity on Neuro-2a cells. METHOD: release, cytotoxicity, histopathological and cell uptake studies using rhodamine loaded P80-NPs. RESULT: and no cytotoxicity in histopathology was observed. Significant higher uptake (96.9%) of P80-modified-NPS was observed as compared to unmodified-NPs (81%) (p < 0.05). CONCLUSION: The finding clearly indicated a higher cell uptake of drugs via surface modified P80-coated PLGA-NPs as compared to unmodified particles.