亚砜
砜
化学
反应性(心理学)
限制
羧酸
组合化学
有机化学
医学
替代医学
病理
机械工程
工程类
作者
Việt Dũng Nguyễn,Graham C. Haug,Samuel G. Greco,Ramon Trevino,Guna B. Karki,Hadi D. Arman,Oleg V. Larionov
标识
DOI:10.1002/anie.202210525
摘要
The intermediate oxidation state of sulfoxides is central to the plethora of their applications in chemistry and medicine, yet it presents challenges for an efficient synthetic access, limiting the structural diversity of currently available sulfoxides. Here, we report a data-guided development of direct decarboxylative sulfinylation that enables the previously inaccessible functional group interconversion of carboxylic acids to sulfoxides in a reaction with sulfinates. Given the broad availability of carboxylic acids and the growing synthetic potential of sulfinates, the direct decarboxylative sulfinylation is poised to improve the structural diversity of synthetically accessible sulfoxides. The reaction is facilitated by a kinetically favored sulfoxide formation from the intermediate sulfinyl sulfones, despite the strong thermodynamic preference for the sulfone formation, unveiling the previously unknown and chemoselective radicalophilic sulfinyl sulfone reactivity.
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