核小体
染色质重塑
染色质
解旋酶
细胞生物学
生物
瑞士/瑞士法郎
染色质结构重塑复合物
AAA蛋白
DNA
组蛋白
ATP酶
螺线管
遗传学
计算生物学
生物化学
基因
酶
物理
核糖核酸
量子力学
作者
Anjanabha Saha,Jacqueline Wittmeyer,Bradley R. Cairns
出处
期刊:Results and problems in cell differentiation
日期:2006-03-30
卷期号:: 127-148
被引量:40
摘要
Chromatin remodeling complexes (remodelers) are a set of diverse multi-protein machines that reposition and restructure nucleosomes. Remodelers are specialized, containing unique proteins that assist in targeting, interaction with modified nucleosomes, and performing specific chromatin tasks. However, all remodelers contain an ATPase domain that is highly similar to known DNA translocases/helicases, suggesting that DNA translocation is a property common to all remodelers. Here we examine the different reactions they perform in vitro, focusing on the SWI/SNF and the ISWI complexes, and explore how DNA translocation might be utilized to execute various remodeling processes.
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