登革热
医学
腹水
内科学
黄疸
登革热病毒
胃肠病学
肝病
丙氨酸转氨酶
肝损伤
肝功能
免疫学
作者
Srivenu Itha,Rajesh Kashyap,Narendra Krishnani,Vivek A. Saraswat,Gourdas Choudhuri,Rakesh Aggarwal
出处
期刊:PubMed
日期:2005-09-01
卷期号:18 (3): 127-30
被引量:59
摘要
Data are scarce on liver involvement in adult patients with dengue virus infection.During a recent outbreak of dengue fever in Uttar Pradesh, India, we looked for evidence of liver dysfunction among patients with dengue fever.A total of 45 patients with dengue fever (age 7-65 [median 33] years; 29 men; 39 adults) were studied, including 23 with uncomplicated dengue fever, 15 with dengue haemorrhagic fever and 7 with dengue shock syndrome. The median platelet count was 34 x 10(9)/L (9-99 x 10(9)). Seven patients (15%) had jaundice, 11 (24%) hepatomegaly and 9 clinically detectable ascites; none had splenomegaly. Twelve patients (30%) had hyperbilirubinaemia. Serum alanine and aspartate aminotransferase activities were elevated in 43 patients (96%) each; 5-fold elevated levels were more frequent in severe disease. Hypoalbuminaemia was found in 31/41 patients (76%). Seven patients died, including 2 with acute liver failure.Our data show that liver injury is common in adult patients with dengue infection. Further studies are needed to determine the mechanism of liver injury in this disease.
科研通智能强力驱动
Strongly Powered by AbleSci AI